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St. Mary Church is a Roman Catholic church serving the Sioux Falls, South Dakota community. The parish provides regular Mass, confession, religious education, and sacramental preparation for parishioners and visitors.
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Embrace Church is a multi-campus church in Sioux Falls, South Dakota that exists to relentlessly reach the next person for Jesus through their values of Encounter, Compassion, Embrace, and Run. Founded in 2006, they operate multiple physical campuses, an online campus, and prison ministries.

Sioux Falls Seventh-day Adventist Church helps people from various walks of life grow closer to God, enhancing quality of life and sharing the message of Jesus' imminent return.

First Presbyterian Church is committed to being the visible face of Christ in Sioux Falls and beyond, welcoming everyone with open minds and hearts. They emphasize inclusivity and support for all individuals on their spiritual journeys.

Bethel Evangelical Lutheran Church and School is a WELS congregation in Sioux Falls, SD, empowered by God's Word to teach, confess, and proclaim Christ crucified. The church also operates a Christian day school serving kindergarten through 8th grade.
Cathedral of Saint Joseph is a Catholic parish located in Sioux Falls, South Dakota, united in the Eucharist and the teachings of the Church. The community gathers for worship, prayer, and service to others.

The Catholic Diocese of Sioux Falls serves Catholics in South Dakota. Its mission centers on building 'Lifelong Catholic Missionary Discipleship Through God's Love,' guided by the diocesan Office of Discipleship and Evangelization through an initiative called 'Set Ablaze,' reflecting Bishop DeGrood's vision.

Holy Spirit Catholic Church is a vibrant parish established in 1988 in Sioux Falls, SD, centered on Jesus Christ in the Eucharist as the source and summit of Catholic faith. The church features a national blue-ribbon school, comprehensive religious education, and active youth and family ministries.

St. Katharine Drexel Catholic Church is part of the diocese of Sioux Falls and aims to help its community encounter Jesus Christ through prayer, the Sacraments, and teachings of the Church.

St. Therese the Little Flower Catholic Church is dedicated to serving the community through various sacraments and youth programs, encouraging members to share their gifts.