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First Presbyterian Church of Muscatine is a Presbyterian Church (U.S.A.) congregation called to worship, serve, love, grow, and dream together. They are committed to Matthew 25 discipleship focused on building congregational vitality, dismantling structural racism, and eradicating systemic poverty.

Wesley United Methodist Church is a community focused on uplifting worship and meaningful community engagement, aiming to transform lives through hands-on ministry with children and families in need.

Pine Mills German Methodist Episcopal Church, constructed in 1867 by German-Americans, served its community until 1910. It was restored in the 2000s and now holds special events, maintaining its historic significance.

Trinity Episcopal Church of Muscatine is a community of faith that emphasizes belonging and support, ensuring fellowship that encourages service both within the church and the wider community.
Saint Mary & Saint Mathias Catholic Church is a Catholic parish located in Muscatine, Iowa, united in the Eucharist and the teachings of the Church. The community gathers for worship, prayer, and service to others.
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